Sh3rf1 ELISA Kit for Mouse(Mus musculus) | EIAab.comSh3rf1 ELISA Kit for Mouse(Mus musculus)

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Sh3rf1 (Gene name),

E3 ubiquitin-protein ligase SH3RF1 (Protein name ), SH3R1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Sh3rf1(Kiaa1494;Posh;Sh3md2);

Protein name:

E3 ubiquitin-protein ligase SH3RF1;

Alternative:

SH3 domain-containing RING finger protein 1;Plenty of SH3s(Protein POSH);SH3 multiple domains protein 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with HERP1 (By similarity). Interacts with Rac; in a GTP-dependent manner. Interacts with MAP3K10 and MAP3K11. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4, MAP2K7, MAPK8, MAPK9, AKT1 and AKT2.

Function:

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis.

Subcellular Location:

Cytoplasm perinuclear region Cell projection lamellipodium Golgi apparatus trans-Golgi network Co-localizes, with AKT2, in lamellipodia (By similarity). Co-localizes, with HERP1, in trans-Golgi network.

Protein Attributes:

Sequence length:

892

Sequence:

50:

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650:

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750:

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892:

ELELKEGDIV | FVHKKREDGW | FKGTLQRNGK | TGLFPGSFVE | NI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q69ZI1

UniGene:

Mm.27949

Pfam:

PF00018

SMR:

Q69ZI1

KEGG:

mmu:59009

Pfam:

PF00097

Uniprot:

Q69ZI1

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ELISA Kit for Mouse E3 ubiquitin-protein ligase SH3RF1

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E15485h

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96T

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ELISA Kit for Mouse E3 ubiquitin-protein ligase SH3RF1

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E15485m

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96T

ELISA Kit for Mouse E3 ubiquitin-protein ligase SH3RF1

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E15485b

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96T

ELISA Kit for Mouse E3 ubiquitin-protein ligase SH3RF1

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E15485r

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96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SH3RF1

Cat.:

U15485m

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96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SH3RF1

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U15485b

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96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SH3RF1

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U15485r

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96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SH3RF1

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U15485h

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96T

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SH3RF1

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P15485Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SH3RF1

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P15485Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SH3RF1

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P15485Rb-m

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Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase SH3RF1

Protein for Mouse E3 ubiquitin-protein ligase SH3RF1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs."
Kukekov N.V. , Xu Z. , Greene L.A.
J. Biol. Chem.281:15517-15524(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK8IP
2.

"A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways."
Tapon N. , Nagata K. , Lamarche N. , Hall A.
EMBO J.17:1395-1404(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH RAC
3.

"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Seino S. , Nishimura M. , Kaisho T. , Hoshino K. , Kitamura H. , Nagase T. , Ohara O. , Koga H.
DNA Res.11:205-218(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Embryonic tail.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 200-892 (ISOFORM 1)
strain: C57BL/6J.
strain: NOD.
tissue: Corpora quadrigemina.
tissue: Thymus.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6.
tissue: Brain.
6.

"POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis."
Xu Z. , Kukekov N.V. , Greene L.A.
EMBO J.22:252-261(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K10; MAP3K11; DLK1; MAP2K4; MAP2K7; MAPK8 AND MAPK9
7.

"Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex."
Figueroa C. , Tarras S. , Taylor J. , Vojtek A.B.
J. Biol. Chem.278:47922-47927(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKT2;MUTAGENESIS OF GLU-470 AND TRP-489;SUBCELLULAR LOCATION
8.

"Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis."
Xu Z. , Sproul A. , Wang W. , Kukekov N. , Greene L.A.
J. Biol. Chem.281:303-312(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIAH1

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